Naphthoxazole and benzoxazole as fluorescent DNA probes – a systematic review
Délis Galvão Guimarães; Victória Laysna dos Anjos Santos; Sidney Silva Simplicio; Larissa Araújo Rolim; Arlan de Assis Gonsalves; Cleônia Roberta Melo Araújo
Abstract
Considering the mutagenic effects and environmental concerns associated with commonly used fluorescent DNA probes, benzoxazoles and naphthoxazoles emerge as sensitive and safer alternatives. Benzoxazoles and naphthoxazoles are attractive from both chemical and biological perspectives. In addition to their multiple biological activities, these compounds exhibit promising photoluminescent properties and other characteristics that are favorable for use as fluorescent DNA probes. This systematic review investigates the potential of benzoxazole and naphthoxazole derivatives to bind to DNA and emit fluorescence. Scientific articles published in the last decade (2012-2023), selected based on pre-established inclusion criteria, indicate the potential of these compounds to bind to DNA and exhibit enhanced fluorescence emission. More than 70% of the compounds evaluated for DNA interaction were naphthoxazole derivatives. All seven assessed compounds showed DNA binding behavior, with intercalation being the predominant mode of interaction, particularly at increasing DNA concentrations. Furthermore, all reported benzoxazoles and naphthoxazoles exhibited increased fluorescence emission intensity with higher DNA concentrations. The results of this study indicate that benzoxazole and naphthoxazole derivatives have significant potential for use as fluorescent DNA probes and suggest considerable opportunities for further research and development in this area.
Keywords
References
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Submitted date:
04/24/2024
Accepted date:
08/04/2024
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