Environmental bacterial species with antimicrobial potential against ESKAPEE pathogens: a scoping review
Andreia Bueno da Silva; Eduardo Santos Biasi; Bruno Paulo Rodrigues Lustosa; Mariana Vieira Porsani; Guilherme Fonseca Reis; Géssica Slompo de Deus; Juliana Thaler; Lorena Carolina Peña; Arandi Ginane Bezerra Jr; Luciano Aparecido Panagio; Marconi Rodrigues de Farias; Ida Chapaval Pimentel; Keite da Silva Nogueira; Vânia Aparecida Vicente
Abstract
Antimicrobial resistance poses a serious threat to global health, complicating the treatment of infectious diseases and increasing mortality rates and healthcare expenditures. Although antibiotic use in some areas has decreased, multidrug-resistant bacteria, especially those among significant pathogens such as ESKAPEE, are a major global challenge. The aim of this review was to gather data on bacterial genera from various environmental sources that synthesize compounds with antimicrobial activity against pathogens belonging to the ESKAPEE group. The MEDLINE/PubMed, Scopus, and Science Direct databases were searched for articles published from 2001 to 2023. The included publications were carefully selected based on their relevance to the topic and methodologies used. In total, 50 articles were reviewed and 20 bacterial genera with significant antimicrobial activity were identified, with Streptomyces spp. being the most prevalent. The bacteria were isolated from different environments, including marine sediments, endophytes, and extreme environments. The evaluation of bacterial extracts against ESKAPEE pathogens revealed considerable inhibition capacities, particularly for Streptomyces spp., Bacillus spp. and Pseudomonas spp. However, no single extract was effective in inhibiting all target pathogens. Furthermore, 33(33/64) bacterial extracts from the 50 studies included in the review characterized, at least partially, the secondary metabolites responsible for the observed antibacterial potential. Twenty patents filed for compounds characterized with antibacterial activity against ESKAPEE bacteria were found. And in the search for marketed products, a total of 22 compounds were found. The discussion highlights the marine environment as a rich source of antimicrobial-producing bacteria due to its unique ecological conditions. Streptomyces spp. remains promising candidates for antibiotic discovery, due to a diverse range of antimicrobial compounds. In conclusion, this review highlights the strong ability of bacteria from a wide range of environments to combat antimicrobial resistance. By elucidating antimicrobial activity and compound characterization, this review provides valuable insights into antibiotic research, crucial to managing the growing threat of multidrug-resistant pathogens.
Keywords
References
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Submitted date:
06/18/2024
Accepted date:
10/31/2024
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