Biotechnology Research and Innovation Journal
http://www.biori.periodikos.com.br/article/doi/10.1016/j.biori.2017.10.005
Biotechnology Research and Innovation Journal
Review Sections Review article

Mesenchymal stem cells from human adipose tissue and bone repair: a literature review

Vivian Alonso-Goulart, Lorraine Braga Ferreira, Cristiane Angélico Duarte, Isabela Lemos de Lima, Enza Rafaela Ferreira, Bárbara Candido de Oliveira, Luna Nascimento Vargas, Dayane Dotto de Moraes, Isaura Beatriz Borges Silva, Rafael de Oliveira Faria, Aline Gomes de Souza, Leticia de Souza Castro-Filice

Downloads: 0
Views: 606

Abstract

Mesenchymal stem cells (MSCs) emerge as potential tools for treatment of various diseases. Isolation methods and tissue of origin are important factors that determine the amount of obtained cells and their ability to differentiate. MSCs can be isolated from adipose tissue (ADSCs), bone marrow (BMSCs) or umbilical cord (UC-MSCs), and its characterization must follow the criteria required by the International Society for Cellular Therapy. Osteogenic differentiation capacity of ADSCs can still vary according to the culture medium used, as well as by adding factors that can alter signaling pathways and enhance bone differentiation. In addition, nanotechnology has also been used to increase osteoblastic induction and differentiation. ADSCs enhanced the prospect of treatment in different diseases, and in regenerative medicine, these cells can also be associated with different biomaterials. There is a great progress in studies with ADSCs, mainly because it is easy to access, which makes bioengineering techniques for bone tissue feasible.

Keywords

Stem cells,  Adipose tissue,  Bone repair  

References

Afanasyev et al., 2009
B.V. Afanasyev, E. Elstner, A.R. Zander
A. J. Friedenstein, founder of the mesenchymal stem cell concept
Cellular Therapy and Transplantation, 1 (3) (2009), 10.3205/ctt-2009-en-000029.01

Ahearne et al., 2014
M. Ahearne, J. Lysaght, A.P. Lynch
Combined influence of basal media and fibroblast growth factor on the expansion and differentiation capabilities of adipose-derived stem cells
Cell Regeneration, 3 (1) (2014), p. 13, 10.1186/2045-9769-3-13

Aust et al., 2004
L. Aust, B. Devlin, S.J. Foster, Y.D.C. Halvorsen, K. Hicok, T. du Laney, ..., J.M. Gimble
Yield of human adipose-derived adult stem cells from liposuction aspirates
Cytotherapy, 6 (1) (2004), pp. 7-14, 10.1080/14653240310004539

Baer et al., 2013
P.C. Baer, S. Kuci, M. Krause, Z. Kuci, S. Zielen, H. Geiger
Comprehensive phenotypic characterization of human adipose-derived stromal/stem cells and their subsets by a high throughput technology
Stem Cells and Development, 22 (2013), 10.1089/scd.2012.0346

Banas et al., 2007
A. Banas, T. Teratani, Y. Yamamoto, M. Tokuhara, F. Takeshita, G. Quinn, ..., T. Ochiya
Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes
Hepatology, 46 (1) (2007), pp. 219-228, 10.1002/hep.21704

Bassi et al., 2012
Ê.J. Bassi, P.M.M. Moraes-Vieira, C.S.R. Moreira-Sá, D.C. Almeida, L.M. Vieira, C.S. Cunha, ..., N.O.S. Câmara
Immune regulatory properties of allogeneic adipose-derived mesenchymal stem cells in the treatment of experimental autoimmune diabetes
Diabetes, 61 (10) (2012), pp. 2534-2545, 10.2337/db11-0844

Bobis-Wozowicz et al., 2014
S. Bobis-Wozowicz, S. Millington-Ward, A. Zawisz, T. Adamus, P. Konieczny, M. Majka
An improved protocol for adipose tissue-derived stem cell isolation: Implications for treatments of bone disorders
European Journal of Medical Technologies, 1 (2014), pp. 16-21

Bourin et al., 2013
P. Bourin, B.A. Bunnell, L. Casteilla, M. Dominici, A.J. Katz, K.L. March
Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: A joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT)
Cytotherapy, 15 (2013), 10.1016/j.jcyt.2013.02.006

Caplan, 1991
A.I. Caplan
Mesenchymal stem cells
Journal of Orthopaedic Research, 9 (5) (1991), pp. 641-650, 10.1002/jor.1100090504

Chen et al., 2015
T. Chen, Y.-w. Wu, H. Lu, Y. Guo, Z.-h. Tang
Adiponectin enhances osteogenic differentiation in human adipose-derived stem cells by activating the APPL1-AMPK signaling pathway
Biochemical and Biophysical Research Communications, 461 (2) (2015), pp. 237-242, 10.1016/j.bbrc.2015.03.168

Choi et al., 2015
S.Y. Choi, M.S. Song, P.D. Ryu, A.T.N. Lam, S.-W. Joo, S.Y. Lee
Gold nanoparticles promote osteogenic differentiation in human adipose-derived mesenchymal stem cells through the Wnt/β-catenin signaling pathway
International Journal of Nanomedicine, 10 (2015), pp. 4383-4392, 10.2147/IJN.S78775

Condé-Green et al., 2014
A. Condé-Green, R.L. Rodriguez, S. Slezak, D.P. Singh, N.H. Goldberg, J. McLenithan
Comparison between stromal vascular cells’ isolation with enzymatic digestion and mechanical processing of aspirated adipose tissue
Plastic and Reconstructive Surgery, 134 (4S-1) (2014), p. 54, 10.1097/01.prs.0000455394.06800.62

DelaRosa et al., 2012
O. DelaRosa, W. Dalemans, E. Lombardo
Mesenchymal stem cells as therapeutic agents of inflammatory and autoimmune diseases
Current Opinion in Biotechnology, 23 (6) (2012), pp. 978-983, 10.1016/j.copbio.2012.05.005

Doi et al., 2013
K. Doi, S. Tanaka, H. Iida, H. Eto, H. Kato, N. Aoi, ..., K. Yoshimura
Stromal vascular fraction isolated from lipo-aspirates using an automated processing system: Bench and bed analysis
Journal of Tissue Engineering and Regenerative Medicine, 7 (11) (2013), pp. 864-870, 10.1002/term.1478

Dominici et al., 2006
M. Dominici, K. Le Blanc, I. Mueller, I. Slaper-Cortenbach, F. Marini, D. Krause, ..., E. Horwitz
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
Cytotherapy, 8 (4) (2006), pp. 315-317, 10.1080/14653240600855905

Fukuchi et al., 2004
Y. Fukuchi, H. Nakajima, D. Sugiyama, I. Hirose, T. Kitamura, K. Tsuji
Human placenta-derived cells have mesenchymal stem/progenitor cell potential
Stem Cells, 22 (5) (2004), pp. 649-658, 10.1634/stemcells.22-5-649

Ghorbani et al., 2014
A. Ghorbani, S.A. Jalali, M. Varedi
Isolation of adipose tissue mesenchymal stem cells without tissue destruction: A non-enzymatic method
Tissue and Cell, 46 (1) (2014), pp. 54-58, 10.1016/j.tice.2013.11.002

Gimble and Guilak, 2003
J. Gimble, F. Guilak
Adipose-derived adult stem cells: Isolation, characterization, and differentiation potential
Cytotherapy, 5 (5) (2003), pp. 362-369, 10.1080/14653240310003026

Godoy Zanicotti et al., 2016
D. Godoy Zanicotti, D.E. Coates, W.J. Duncan
In vivo bone regeneration on titanium devices using serum-free grown adipose-derived stem cells, in a sheep femur model
Clinical Oral Implants Research (2016), 10.1111/clr.12761

González-Fernández et al., 2015
M.L. González-Fernández, S. Pérez-Castrillo, P. Ordás-Fernández, M.E. López-González, B. Colaço, V. Villar-Suárez
Study on viability and chondrogenic differentiation of cryopreserved adipose tissue-derived mesenchymal stromal cells for future use in regenerative medicine
Cryobiology, 71 (2) (2015), pp. 256-263, 10.1016/j.cryobiol.2015.07.007

Gu et al., 2015
H. Gu, Z. Huang, X. Yin, J. Zhang, L. Gong, J. Chen, ..., L. Cui
Role of c-Jun N-terminal kinase in the osteogenic and adipogenic differentiation of human adipose-derived mesenchymal stem cells
Experimental Cell Research, 339 (1) (2015), pp. 112-121, 10.1016/j.yexcr.2015.08.005

Guven et al., 2012
S. Guven, M. Karagianni, M. Schwalbe, S. Schreiner, J. Farhadi, S. Bula, ..., A. Scherberich
Validation of an automated procedure to isolate human adipose tissue-derived cells by using the Sepax(R) technology
Tissue Engineering Part C: Methods, 18 (8) (2012), pp. 575-582, 10.1089/ten.TEC.2011.0617

Heo et al., 2016
J.S. Heo, Y. Choi, H.S. Kim, H.O. Kim
Comparison of molecular profiles of human mesenchymal stem cells derived from bone marrow, umbilical cord blood, placenta and adipose tissue
International Journal of Molecular Medicine, 37 (1) (2016), pp. 115-125, 10.3892/ijmm.2015.2413

Hermida-Gomez et al., 2011
T. Hermida-Gomez, I. Fuentes-Boquete, M.J. Gimeno-Longas, E. Muinos-Lopez, S. Diaz-Prado, F.J. de Toro, F.J. Blanco
Quantification of cells expressing mesenchymal stem cell markers in healthy and osteoarthritic synovial membranes
The Journal of Rheumatology, 38 (2) (2011), pp. 339-349, 10.3899/jrheum.100614

Hong et al., 2009
D. Hong, H.X. Chen, Y. Xue, D.M. Li, X.C. Wan, R. Ge, J.C. Li
Osteoblastogenic effects of dexamethasone through upregulation of TAZ expression in rat mesenchymal stem cells
The Journal of Steroid Biochemistry and Molecular Biology, 116 (2009), 10.1016/j.jsbmb.2009.05.007

Kargozar et al., 2016
S. Kargozar, M. Mozafari, S.J. Hashemian, P. Brouki Milan, S. Hamzehlou, M. Soleimani, ..., A.M. Seifalian
Osteogenic potential of stem cells-seeded bioactive nanocomposite scaffolds: A comparative study between human mesenchymal stem cells derived from bone, umbilical cord Wharton's jelly, and adipose tissue
Journal of Biomedical Materials Research Part B: Applied Biomaterials (2016), 10.1002/jbm.b.33814

Landerholm and Chapman, 2014
T. Landerholm, J.R. Chapman
Comparison between collagenase adipose digestion and Stromacell mechanical dissociation for mesenchymal stem cell separation
McNair Scholars Journal, 15 (2014)

Langenbach and Handschel, 2013
F. Langenbach, J. Handschel
Effects of dexamethasone, ascorbic acid and β-glycerophosphate on the osteogenic differentiation of stem cells in vitro
Stem Cell Research & Therapy, 4 (5) (2013), p. 117, 10.1186/scrt328

Langenbach et al., 2013
F. Langenbach, C. Naujoks, R. Smeets, K. Berr, R. Depprich, N. Kubler, J. Handschel
Scaffold-free microtissues: Differences from monolayer cultures and their potential in bone tissue engineering
Clinical Oral Investigations, 17 (2013), 10.1007/s00784-012-0763-8

Li et al., 2014
X. Li, J. Bai, X. Ji, R. Li, Y. Xuan, Y. Wang
Comprehensive characterization of four different populations of human mesenchymal stem cells as regards their immune properties, proliferation and differentiation
International Journal of Molecular Medicine, 34 (3) (2014), pp. 695-704, 10.3892/ijmm.2014.1821

Liu et al., 2008
G. Liu, H. Zhou, Y. Li, G. Li, L. Cui, W. Liu, Y. Cao
Evaluation of the viability and osteogenic differentiation of cryopreserved human adipose-derived stem cells
Cryobiology, 57 (1) (2008), pp. 18-24, 10.1016/j.cryobiol.2008.04.002

Ma et al., 2014
S. Ma, N. Xie, W. Li, B. Yuan, Y. Shi, Y. Wang
Immunobiology of mesenchymal stem cells
Cell Death and Differentiation, 21 (2) (2014), pp. 216-225, 10.1038/cdd.2013.158

Mafi et al., 2011
P. Mafi, S. Hindocha, R. Mafi, M. Griffin, W.S. Khan
Adult mesenchymal stem cells and cell surface characterization – A systematic review of the literature
The Open Orthopaedics Journal, 5 (2011), pp. 253-260, 10.2174/1874325001105010253

Markarian et al., 2014
C.F. Markarian, G.Z. Frey, M.D. Silveira, E.M. Chem, A.R. Milani, P.B. Ely, ..., M. Camassola
Isolation of adipose-derived stem cells: A comparison among different methods
Biotechnology Letters, 36 (4) (2014), pp. 693-702, 10.1007/s10529-013-1425-x

Mesimaki et al., 2009
K. Mesimaki, B. Lindroos, J. Tornwall, J. Mauno, C. Lindqvist, R. Kontio, ..., R. Suuronen
Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells
International Journal of Oral and Maxillofacial Surgery, 38 (3) (2009), pp. 201-209, 10.1016/j.ijom.2009.01.001

Minonzio et al., 2014
G. Minonzio, M. Corazza, L. Mariotta, M. Gola, M. Zanzi, E. Gandolfi, ..., G. Soldati
Frozen adipose-derived mesenchymal stem cells maintain high capability to grow and differentiate
Cryobiology, 69 (2) (2014), pp. 211-216, 10.1016/j.cryobiol.2014.07.005

Mosna et al., 2010
F. Mosna, L. Sensebe, M. Krampera
Human bone marrow and adipose tissue mesenchymal stem cells: A user's guide
Stem Cells and Development, 19 (10) (2010), pp. 1449-1470, 10.1089/scd.2010.0140

Park et al., 2011
J.C. Park, J.M. Kim, I.H. Jung, J.C. Kim, S.H. Choi, K.S. Cho, C.S. Kim
Isolation and characterization of human periodontal ligament (PDL) stem cells (PDLSCs) from the inflamed PDL tissue: In vitro and in vivo evaluations
Journal of Clinical Periodontology, 38 (8) (2011), pp. 721-731, 10.1111/j.1600-051X.2011.01716.x

Peng et al., 2009
S. Peng, G. Zhou, K.D.K. Luk, K.M.C. Cheung, Z. Li, W.M. Lam, ..., W.W. Lu
Strontium promotes osteogenic differentiation of mesenchymal stem cells through the Ras/MAPK signaling pathway
Cellular Physiology and Biochemistry, 23 (1–3) (2009), pp. 165-174

Pittenger et al., 1999
M.F. Pittenger, A.M. Mackay, S.C. Beck, R.K. Jaiswal, R. Douglas, J.D. Mosca, ..., D.R. Marshak
Multilineage potential of adult human mesenchymal stem cells
Science, 284 (5411) (1999), pp. 143-147

Rozila et al., 2016
I. Rozila, P. Azari, S. Munirah, W.K. Wan Safwani, S.N. Gan, A.G. Nur Azurah, ..., K.H. Chua
Differential osteogenic potential of human adipose-derived stem cells co-cultured with human osteoblasts on polymeric microfiber scaffolds
Journal of Biomedical Materials Research Part A, 104 (2) (2016), pp. 377-387, 10.1002/jbm.a.35573

Sakaguchi et al., 2004
Y. Sakaguchi, I. Sekiya, K. Yagishita, S. Ichinose, K. Shinomiya, T. Muneta
Suspended cells from trabecular bone by collagenase digestion become virtually identical to mesenchymal stem cells obtained from marrow aspirates
Blood, 104 (9) (2004), p. 2728

Samsonraj et al., 2015
R.M. Samsonraj, B. Rai, P. Sathiyanathan, K.J. Puan, O. Rötzschke, J.H. Hui, ..., S.M. Cool
Establishing criteria for human mesenchymal stem cell potency
Stem Cells, 33 (6) (2015), pp. 1878-1891, 10.1002/stem.1982

Sándor et al., 2014
G.K. Sándor, J. Numminen, J. Wolff, T. Thesleff, A. Miettinen, V.J. Tuovinen, ..., J. Öhman
Adipose stem cells used to reconstruct 13 cases with cranio-maxillofacial hard-tissue defects
Stem Cells Translational Medicine, 3 (4) (2014), pp. 530-540, 10.5966/sctm.2013-0173

Schwab et al., 2008
K.E. Schwab, P. Hutchinson, C.E. Gargett
Identification of surface markers for prospective isolation of human endometrial stromal colony-forming cells
Human Reproduction, 23 (4) (2008), pp. 934-943, 10.1093/humrep/den051

Song et al., 2009
I.H. Song, A.I. Caplan, J.E. Dennis
Dexamethasone inhibition of confluence-induced apoptosis in human mesenchymal stem cells
Journal of Orthopaedic Research, 27 (2009), 10.1002/jor.20726

Song et al., 2016
K. Song, Y. Yang, L. Xu, J. Tian, J. Fan, Z. Jiao, ..., T. Liu
Fabrication and detection of tissue engineered bone aggregates based on encapsulated human ADSCs within hybrid calcium alginate/bone powder gel-beads in a spinner flask
Materials Science and Engineering C, 62 (2016), pp. 787-794, 10.1016/j.msec.2016.02.036

Tenenbaum and Heersche, 1985
H.C. Tenenbaum, J.N. Heersche
Dexamethasone stimulates osteogenesis in chick periosteum in vitro
Endocrinology, 117 (1985), 10.1210/endo-117-5-2211

Tobita et al., 2008
M. Tobita, A.C. Uysal, R. Ogawa, H. Hyakusoku, H. Mizuno
Periodontal tissue regeneration with adipose-derived stem cells
Tissue Engineering Part A, 14 (6) (2008), pp. 945-953, 10.1089/ten.tea.2007.0048

Walsh et al., 2001
S. Walsh, G.R. Jordan, C. Jefferiss, K. Stewart, J.N. Beresford
High concentrations of dexamethasone suppress the proliferation but not the differentiation or further maturation of human osteoblast precursors in vitro: Relevance to glucocorticoid-induced osteoporosis
Rheumatology, 40 (2001), 10.1093/rheumatology/40.1.74

Yang et al., 2017
J. Yang, X. Chen, T. Yuan, X. Yang, Y. Fan, X. Zhang
Regulation of the secretion of immunoregulatory factors of mesenchymal stem cells (MSCs) by collagen-based scaffolds during chondrogenesis
Materials Science and Engineering C: Materials for Biological Applications, 70 (Pt 2) (2017), pp. 983-991, 10.1016/j.msec.2016.04.096

Yarak and Okamoto, 2010
S. Yarak, O.K. Okamoto
Human adipose-derived stem cells: Current challenges and clinical perspectives
Anais Brasileiros de Dermatologia, 85 (5) (2010), pp. 647-656

Yoshimura et al., 2006
K. Yoshimura, T. Shigeura, D. Matsumoto, T. Sato, Y. Takaki, E. Aiba-Kojima, ..., K. Gonda
Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates
Journal of Cellular Physiology, 208 (1) (2006), pp. 64-76, 10.1002/jcp.20636

Zhang et al., 2005
H. Zhang, Z. Miao, Z. He, Y. Yang, Y. Wang, M. Feng
The existence of epithelial-to-mesenchymal cells with the ability to support hematopoiesis in human fetal liver
Cell Biology International, 29 (3) (2005), pp. 213-219, 10.1016/j.cellbi.2004.12.007

Zuk et al., 2002
P.A. Zuk, M. Zhu, P. Ashjian, D.A. De Ugarte, J.I. Huang, H. Mizuno, ..., M.H. Hedrick
Human adipose tissue is a source of multipotent stem cells
Molecular Biology of the Cell, 13 (12) (2002), pp. 4279-4295, 10.1091/mbc.E02-02-0105

608b0672a953954a4c2ed103 biori Articles
Links & Downloads

BIORI

Share this page
Page Sections